TekLeu® PEO Polyethylene oxide (PEO), a nonionic hydrophilic polymer, is one of the most widely used polymers for extending the drug release.
Molecule Structure
CAS# | 25322-68-3 |
Features & Benefits
■ Low toxicity when applied to various drug delivery routes;
■ Hydrate quickly to form a gel when applied to hydrophilic matrix tablets;
■ Wide range of molecular weights makes the formulation more flexible;
■ It have excellent lubricity when wet, and this property has been used to improve medical device coatings;
■ Polyethylene Oxide with high molecular weight delays drug release by swelling the hydrophilic matrix;
Storage & Handling
Store in a dry and tightly sealed container;
Packing: 1kg Aluminum bag/ 5kg drum/ 20kg drum;
Regulatory
DMF,CEP,GMP
Safety
Safety Data Sheet has been compiled for Polyethylene Oxide (TekLeu® PEO) that contains up-to-date information on questions relevant to safety.
Application
Application | Dosage | Example |
Sustained release skeleton material | 10-30% | Nifedipine Controlled-release Tablets |
Physical & Chemical properties
Standard | CP2020; USP; EP | |
White to off-white, free-flowing powder; with a slight ammonia odor. Soluble in water and many common organic solvents, such as acetonitrile, chloroform, dichloromethane, insoluble in aliphatic hydrocarbons, ethylene glycol and ethanol. | ||
Libertia Code | Labeled average molecular weight | Dynamic viscosity（mPa·s）Polyethylene Oxide(g)/ (Water+Isopropyl alcohol）(ml) |
PEO-10 | 100,000 | 12〜50(mPa·s)30g/(570+125)ml |
PEO-20 | 200,000 | 65〜115(mPa·s)30g/(570+125) |
PEO-40 | 400,000 | |
PEO-60 | 600,000 | |
PEO-90 | 900,000 | |
PEO-100 | 1,000,000 | |
PEO-200 | 2,000,000 | 2000〜4000(mPa·s)12g/（588+ 125)ml |
PEO-400 | 4,000,000 | |
PEO-500 | 5,000,000 | 5500〜7500(mPa·s)6g/(594+125)ml |
PEO-700 | 7,000,000 | 7500〜10 000(mPa·s)6g/(594+125)ml |